abstract：:It has been shown that the incidence of cognitive impairment increases with the severity of chronic kidney disease (CKD). A previous study has demonstrated that hippocampal oxidative stress contributes to cognitive dysfunction in CKD model mice. Endoplasmic reticulum (ER) stress is thought to contribute significantly ...

journal_title：Neuroscience letters

authors： Kosuge Y,Osada N,Shimomura A,Miyagishi H,Wada T,Ishige K,Shimba S,Ito Y

更新日期：2018-06-11 00:00:00

abstract：:The pathogenic mechanism underlying Parkinson's disease (PD) and PD- Cognitive impairment (CI) remains elusive. Its potential link to the risk factors in Alzheimer's disease (AD) is unclear. In this study, we analyzed 16 CE-associated single nucleotide polymorphisms (SNPs) in twelve genes in a Chinese cohort of 450 PD...

journal_title：Neuroscience letters

authors： Fang L,Tang BS,Fan K,Wan CM,Yan XX,Guo JF

更新日期：2018-06-11 00:00:00

abstract：:Alzheimer disease (AD) is the most common type of dementia, and is currently incurable. The efficacy of existing treatments for AD such as acetylcholinesterase inhibitors is limited to symptom improvement. Research on disease-modifying therapies (DMTs) has conventionally focused on amelioration of CNS pathogenesis. Tw...

journal_title：Neuroscience letters

authors： Shozawa H,Oguchi T,Tsuji M,Yano S,Kiuchi Y,Ono K

更新日期：2018-06-11 00:00:00

abstract：:Early life nutrition is critical for brain development. Dietary prebiotics and bioactive milk fractions support brain development by increasing plasticity and altering activity in brain regions important for cognition and emotion regulation, perhaps through the gut-microbiome-brain axis. Here we examined the impact of...

journal_title：Neuroscience letters

authors： Mika A,Gaffney M,Roller R,Hills A,Bouchet CA,Hulen KA,Thompson RS,Chichlowski M,Berg BM,Fleshner M

更新日期：2018-06-11 00:00:00

abstract：:New psychoactive substances (NPSs), i.e., newly designed substances with chemical residues that are slightly different from those of known psychoactive substances, have been emerging since the late 2000s, and social problems related to the use of these substances are increasing globally. Two such NPSs are 4-chloro-2,5...

journal_title：Neuroscience letters

authors： Cha HJ,Jeon SY,Jang HJ,Shin J,Kim YH,Suh SK

更新日期：2018-05-29 00:00:00

abstract：:Transverse sections of the monkey cervical spinal cord from a previous study (Jenny and Inukai, 1983) were reanalyzed using Neurolucida to create a three-dimensional display of extensor digitorum communis (EDC) motoneurons and proximal dendrites that had been labeled with horse radish peroxidase (HRP). The EDC motoneu...

journal_title：Neuroscience letters

authors： Jenny AB,Cheney PD,Jenny AK

更新日期：2018-05-14 00:00:00

abstract：:Auditory steady-state responses (ASSRs) are increasingly used in research of neuropsychiatric disorders and for brain-computer interface applications. However, results on attentional modulation of ASSRs are inconclusive. The evaluation of large-scale effects of task-related modulation on ASSRs might give better estima...

journal_title：Neuroscience letters

authors： Griskova-Bulanova I,Pipinis E,Voicikas A,Koenig T

更新日期：2018-05-01 00:00:00

abstract：:Spirulina maxima is a blue-green micro alga that contains abundant amounts of proteins (60-70%), vitamins, chlorophyll a, and C-phycocyanin (C-PC). It has been shown to reduce oxidative stress, and prevent diabetes and non-alcoholic fatty liver disease. However, it is unclear whether Spirulina maxima 70% ethanol extra...

journal_title：Neuroscience letters

authors： Koh EJ,Kim KJ,Choi J,Kang DH,Lee BY

更新日期：2018-04-23 00:00:00

abstract：:Central diabetes insipidus can occur after hypothalamic-hypophyseal tract injury. This injury is linked with a deficit in circulating vasopressin and oxytocin, which are produced in the supraoptic nuclei and the hypothalamic paraventricular nuclei. Previous studies indicate that an ectopic neural lobe forms after pitu...

journal_title：Neuroscience letters

authors： Feng Z,Ou Y,Zhou M,Wu G,Ma L,Zhang Y,Liu Y,Qi S

更新日期：2018-04-23 00:00:00

abstract：BACKGROUND:Perinatal hypoxic-ischemic insult is considered a major contributor to child mortality and morbidity and leads to neurological deficits in newborn infants. There has been a lack of promising neurotherapeutic interventions for hypoxic-ischemic brain damage (HIBD) for clinical application in infants. The prese...

journal_title：Neuroscience letters

authors： Zhu H,Qiao L,Sun Y,Yin L,Huang L,Jiang L,Li J

更新日期：2018-04-23 00:00:00

abstract：:It is well known that the CaVα2δ auxiliary subunit regulates the density of high voltage-activated Ca2+ channels in the plasma membrane and that alterations in their functional expression might have implications in the pathophysiology of diverse human diseases such as neuropathic pain. However, little is known concern...

journal_title：Neuroscience letters

authors： González-Ramírez R,Martínez-Hernández E,Sandoval A,Gómez-Mora K,Felix R

更新日期：2018-04-23 00:00:00

abstract：:Existing literature concerning the effect of experimentally-induced diabetes on pain thresholds in rodent models remains controversial. In this work, we describe a phenotypical switch from streptozotocin-induced pinprick hypoalgesia to hyperalgesia observed in the same laboratory, in the same strain of rats, obtained ...

journal_title：Neuroscience letters

authors： Yadlapalli JSK,Dogra N,Walbaum AW,Prather PL,Crooks PA,Dobretsov M

更新日期：2018-04-23 00:00:00

abstract：:We investigated corticospinal excitability during positive (execution) and negative (suppression) imageries for the right and left upper and lower limbs. In the Positive Imagery tasks, sixteen subjects were instructed to repeatedly imagine rotation of the index finger of the right or left hand, or the ankle of the rig...

journal_title：Neuroscience letters

authors： Yokota H,Mizuguchi N,Kakigi R,Nakata H

更新日期：2018-04-13 00:00:00

abstract：:Satellite glial cells (SGCs) surround the neurons in sympathetic ganglia and are believed to make important contributions to the function of the ganglia under normal and pathological conditions. It has been proposed that SGCs communicate chemically with the neurons, but little is known about their pharmacological prop...

journal_title：Neuroscience letters

authors： Feldman-Goriachnik R,Wu B,Hanani M

更新日期：2018-04-03 00:00:00

abstract：:The extent to which N-Methyl-d-aspartate (NMDA) receptors facilitate the motivation to voluntarily wheel-run in rodents has yet to be determined. In so, we utilized female Wistar rats selectively bred to voluntarily run high (HVR) and low (LVR) nightly distances in order to examine if endogenous differences in nucleus...

journal_title：Neuroscience letters

authors： Grigsby KB,Kovarik CM,Rottinghaus GE,Booth FW

更新日期：2018-04-03 00:00:00

abstract：:Recently, researchers have developed protocols for human cerebral organoids using human pluripotent stem cells, which mimic the structure of the developing human brain. Existing research demonstrated that human cerebral organoids which undergo short cultivation periods, contain astrocytes, neurons, and neural stem cel...

journal_title：Neuroscience letters

authors： Matsui TK,Matsubayashi M,Sakaguchi YM,Hayashi RK,Zheng C,Sugie K,Hasegawa M,Nakagawa T,Mori E

更新日期：2018-03-23 00:00:00

abstract：:Crack is a central nervous system stimulant extracted from the Erythroxylum coca plant. It is considered the most potent and addictive form of cocaine, and its euphoric effects are attained within a few seconds after consumption. Alteration of biological markers of oxidative stress and brain-derived neurotrophic facto...

journal_title：Neuroscience letters

authors： Hirsch GE,Jaskulski M,Hamerski HM,Porto FG,da Silva B,Aita CAM,Kroker K,de Bem Silveira G,Silveira PCL,Santos GT,Klafke JZ,Viecili PRN

更新日期：2018-03-23 00:00:00

abstract：:Neuropathic pain (NP) is highly disabling, responds poorly to pharmacological treatment, and represents a significant cause of decreased quality of life in patients suffering from spinal cord injury (SCI). In recent years, cell therapy with autologous mesenchymal stromal cells (MSCs) has been considered as a potential...

journal_title：Neuroscience letters

authors： Vaquero J,Zurita M,Rico MA,Aguayo C,Fernández C,Gutiérrez R,Rodríguez-Boto G,Saab A,Hassan R,Ortega C

更新日期：2018-03-23 00:00:00

abstract：:Personalized or precision medicine is a medical discipline that proposes tailoring health care to each individual by integrating data from their genetic makeup, epigenetic modifications, other biomarkers, clinical symptoms and environmental exposures. Currently, patients typically present for treatment of mood disorde...

journal_title：Neuroscience letters

authors： Prendes-Alvarez S,Nemeroff CB

更新日期：2018-03-16 00:00:00

abstract：:Mood stabilizers are a category of medications used in the management of mood disorders. The mood stabilizing properties of lithium were first reported in 1949 by John Cade, and since then it has been considered the first line treatment for bipolar disorder. Despite presenting more differences than similarities, mood ...

journal_title：Neuroscience letters

authors： Pisanu C,Papadima EM,Del Zompo M,Squassina A

更新日期：2018-03-16 00:00:00

abstract：:The first psychotic episode is classically viewed as a critical period which management is important in determining the long-term outcome of the schizophrenia (SCZ). For this reason, the duration of untreated illness (DUI), defined as the interval between the onset of the psychiatric disorder and the administration of...

journal_title：Neuroscience letters

authors： Murru A,Carpiniello B

更新日期：2018-03-16 00:00:00

abstract：:Cigarette smoking is highly addictive and modern genetic research has identified robust genetic influences on nicotine dependence. An important step in translating these genetic findings to clinical practice is identifying the genetic factors affecting smoking cessation in order to enhance current smoking cessation tr...

journal_title：Neuroscience letters

authors： Chen LS,Horton A,Bierut L

更新日期：2018-03-16 00:00:00

abstract：:Acute physical exercise (APE) induces an increase in the individual alpha peak frequency (iAPF), a cortical parameter associated with neural information processing speed. The aim of this study was to further scrutinize the influence of different APE intensities on post-exercise iAPF as well as its time course after ex...

journal_title：Neuroscience letters

authors： Gutmann B,Zimmer P,Hülsdünker T,Lefebvre J,Binnebößel S,Oberste M,Bloch W,Strüder HK,Mierau A

更新日期：2018-03-06 00:00:00

abstract：:Oligodendrocyte precursor cells (OPCs) play critical roles in maintaining the number of oligodendrocytes in white matter. Previously, we have shown that oxidative stress dampens oligodendrocyte regeneration after white matter damage, while a clinically proven radical scavenger, edaravone, supports oligodendrocyte repo...

journal_title：Neuroscience letters

authors： Takase H,Liang AC,Miyamoto N,Hamanaka G,Ohtomo R,Maki T,Pham LD,Lok J,Lo EH,Arai K

更新日期：2018-03-06 00:00:00

abstract：:Smoking cessation strategies are of prime medical importance. Despite availability of various pharmacological agents in combating addiction to nicotine, more effective medications are needed. Based on recent findings, the glutamatergic system in the brain may provide novel targets. Here, we evaluated the effects of ac...

journal_title：Neuroscience letters

authors： Rezvani AH,Tizabi Y,Slade S,Getachew B,Levin ED

更新日期：2018-03-06 00:00:00

abstract：:Auditory learning induces frequency-specific plasticity in the auditory cortex. Both the auditory cortex and thalamus are involved in the cortical plasticity; however, the precise role of the intracortical circuity remains unclear until the contributions of the thalamocortical inputs are controlled. Here, we induced c...

journal_title：Neuroscience letters

authors： Kong L,Wang S,Liu X,Li L,Zeeman M,Yan J

更新日期：2018-03-06 00:00:00

abstract：:The anti-neuroinflammatory effect of Astragaloside IV (ASI) has been reported, but its underlying mechanisms are unclear. This study is further to explore the underlying mechanism of ASI on anti-neuroinflammatory effect in LPS induced microglia cells. The result showed ASI significantly reduced the production of infla...

journal_title：Neuroscience letters

authors： Li C,Yang F,Liu F,Li D,Yang T

更新日期：2018-02-14 00:00:00

abstract：:The serotonergic dorsal raphé nucleus (DRN) expresses glucocorticoid receptors (GR), and systemic glucocorticoids have been shown to regulate expression and activity of tryptophan hydroxylase isoform 2, the rate-limiting enzyme for serotonin synthesis in brain. We have used intra-DRN injection of pseudotyped adeno-ass...

journal_title：Neuroscience letters

authors： Vincent MY,Donner NC,Smith DG,Lowry CA,Jacobson L

更新日期：2018-02-05 00:00:00

abstract：:As a prevalent disease all over the world, changed functional activities and/or structures in many brain regions have been found in depression. In this study, 5-week chronic restraint stress (CRS) was performed to establish depression rat models, and 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) wa...

journal_title：Neuroscience letters

authors： Wei K,Bao W,Zhao Z,Zhou W,Liu J,Wei Y,Li M,Wu X,Liu B,Du Y,Gong W,Dong J

更新日期：2018-02-05 00:00:00

abstract：:It was accepted for a long time that in mammals there is only retinofugal neuronal connection between the eye and the pineal body (PB). In our previous paper we described that nerve cells were present in hamster PB and these neurons could establish a reverse connection with the retina through a transsynaptic pathway. ...

journal_title：Neuroscience letters

authors： Csáki Á,Vereczki V,Lukáts Á,Boldogkői Z,Sebestyén A,Puskár Z,Köves K

更新日期：2018-02-05 00:00:00

abstract：:Long-term repeated application of morphine induces plasticity changes in sensitive neurons, which represents the neurobiological basis of morphine addiction. Caveolin-1 (Cav-1) is an important scaffolding protein that plays a key role in the regulation of neurostructural plasticity. However, in-depth studies focused o...

journal_title：Neuroscience letters

authors： Cui W,Ren Y,Wang S,Zeng M,Han S,Li J,Han R

更新日期：2018-02-05 00:00:00

abstract：:Miyoshi myopathy (MM) is an autosomal recessive distal muscular dystrophy caused by mutations in the dysferlin gene (DYSF), a 150-kb gene on chromosome 2p13 that contains 55 coding exons. Many patients with MM harbour mutations in the DYSF gene, and most of these mutations are inherited from the patients' parents. Rec...

journal_title：Neuroscience letters

authors： Hu YY,Lian YJ,Xu HL,Zheng YK,Li CF,Zhang JW,Yan SP

更新日期：2018-01-18 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) is a promising method for use in the clinical field, as it can induce modulation of cortical excitability. Generally, rTMS inhibits the motor cortex when delivered at less than 1 Hz. However, it has been indicated that a facilitative effect is induced by 1 Hz rTMS, d...

journal_title：Neuroscience letters

authors： Nojima K,Iramina K

更新日期：2018-01-18 00:00:00

abstract：BACKGROUND:The etiology of neurodegenerative disease remains unclear. Recently, SNP rs11868035, located in an intron of the sterol regulatory element binding factor (SREBF1) gene, was found to be associated with Parkinson's disease (PD) in a large European population in a genome-wide association study. To examine the p...

journal_title：Neuroscience letters

authors： Yuan X,Cao B,Wu Y,Chen Y,Wei Q,Ou R,Yang J,Chen X,Zhao B,Song W,Shang H

更新日期：2018-01-18 00:00:00

abstract：:Although first mentions about calcium disturbances in psychiatric diseases appeared more than 30 years ago, the most recent genomic and proteomic findings confirmed a significant role of Ca2+ and Ca2+-regulated pathways in development of neuropathological processes, including bipolar disorder and schizophrenia. Moreov...

journal_title：Neuroscience letters

authors： Lisek M,Boczek T,Zylinska L

更新日期：2018-01-10 00:00:00

abstract：:The plasma membrane Ca2+-ATPase (PMCA) pumps play a critical role in the maintenance of calcium (Ca2+) homeostasis, crucial for optimal neuronal function and cell survival. Loss of Ca2+ homeostasis is a key precursor in neuronal dysfunction associated with brain aging and in the pathogenesis of neurodegenerative disor...

journal_title：Neuroscience letters

authors： Zaidi A,Adewale M,McLean L,Ramlow P

更新日期：2018-01-10 00:00:00

abstract：:Ca2+ signals regulate most aspects of animal cell life. They are of particular importance to the nervous system, in which they regulate specific functions, from neuronal development to synaptic plasticity. The homeostasis of cell Ca2+ must thus be very precisely regulated: in all cells Ca2+ pumps transport it from the...

journal_title：Neuroscience letters

authors： Calì T,Brini M,Carafoli E

更新日期：2018-01-10 00:00:00

abstract：:Plasma studies depict collisionless, collective movements of charged particles. In touch with these concepts, originally developed by the far-flung branch of high energy physics, here we evaluate the role of collective behaviors and long-range functional couplingsof charged particlesin brain dynamics. We build a novel...

journal_title：Neuroscience letters

authors： Tozzi A,Peters JF,Déli E

更新日期：2018-01-01 00:00:00

abstract：:Recent studies have suggested the involvement of some metabolic hormones in memory formation and synaptic plasticity. Insulin dysfunction is known as an essential process in the pathogenesis of sporadic Alzheimer's disease (AD). In this study we examined whether adiponectin (ADN), as an insulin-sensitizing adipokine, ...

journal_title：Neuroscience letters

authors： Pousti F,Ahmadi R,Mirahmadi F,Hosseinmardi N,Rohampour K

更新日期：2018-01-01 00:00:00

abstract：:The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene has been reported to be a candidate gene for susceptibility to Parkinson's disease (PD), but results of different studies are conflicting. Here, we conducted a meta-analysis of published case-control studies to evaluate the association between MTHFR C677T and A...

journal_title：Neuroscience letters

authors： Liu L,Zhang L,Guo L,Yu Q,Li H,Teng J,Xie A

更新日期：2018-01-01 00:00:00